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Nicotine Only two pre-clinical investigations on the effects of GLP-1RAs in nicotine misuse were retrieved, both showing less nicotine use and related outcomes (for example, withdrawal-induced hyperphagia) for liraglutide 108 and exendin-4 possibly related to dopamine regulation 106

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The explanation for the discrepancy in the reduction of MACE in patients treated with SGLT2i in DECLARE-TIMI 58 suggests that the benefits of SGLT2i may be more pronounced in patients with a higher risk of cardiovascular disease

This therapy is commonly considered when: Weight management has been difficult despite lifestyle efforts Blood sugar or metabolic markers require clinical support Appetite regulation is a concern Ongoing provider monitoring is preferred Men receiving care at our Mandeville clinic are evaluated individually to ensure GLP-1 therapy aligns with their health profile and treatment goals

doi: 10.1016/j.jacl.2021.05.007 268 WongCKMcLeanBABaggioLLKoehlerJAHammoudRRittigNet al