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These effects were shown to be independent of aldosterone, a known regulator of ENaC-dependent sodium reabsorption [25, 26]

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Vitamin C, being a powerful antioxidant, helps neutralize these free radicals, preventing oxidative stress on the skin

A programme of phase 3 trials with retatrutide (TRIUMPH) is ongoing with an aim to assess the safety and efficacy of retatrutide in different populations living with obesity (OSA, T2D, established cardiovascular disease, osteoarthritis)

Although they appropriately used inverse probability of treatment weighting to control for confounding, this approach does not ensure clinical equipoise, limiting causal interpretation because the comparison includes patients who may never have been appropriate candidates for treatment