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In clinical trials, patients taking Mounjaro lost a significant amount of weight (more than patients on Ozempic or Wegovy)

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However, some patients report cognitive changes that may relate to rapid weight loss, caloric restriction, dehydration from gastrointestinal side effects, or nutritional factors rather than direct medication effects

Leo I, Nakou E, Artico J, Androulakis E, Wong J, Moon JC, et al

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Nature 566 , 279283 (2019)