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Low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and total cholesterol all dramatically rise in non-smokers while falling in smokers, whereas these reduced in smokers (65)

NICE guideline NG145 recommends monitoring TSH every 68 weeks after any change in levothyroxine dose, and then annually once stable

Other possible but uncommon side effects are Acute pancreatitis, cholecystitis, cholelithiasis, anaphylaxis, injection site sensitivity, thrombocytopenia, progression of thyroid cancers if present

In MASLD, fat accumulation and oxidative stress in the liver lead to the activation of Kupffer cells

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