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To improve the cardiovascular benefits of GLP-1RAs, we elected to target LDL-C lowering by fusing a GLP-1 analogue peptide to a neutralizing PCSK9 monoclonal antibody

10.1038/5965 183 StranoS.MontiO.PediconiN.BaccariniA.FontemaggiG.LapiE.et al (2005)

CGD is characterized by an inability of phagocytic cells to kill invading microbes that they have engulfed because these cells lack the ability to generate reactive oxygen species such as H 2 O 2