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At 1.7 mg, the GLP-1 receptor activation is near its peak

Gastrointestinal Adverse Events Of the adverse effects reported during GLP-1 RA clinical trials, gastrointestinal symptoms were the most frequent, with nausea and diarrhea very common, and vomiting, constipation, abdominal pain, and dyspepsia considered to be relatively common [97]

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Purine metabolism, ABC transporters, Renin secretion, FoxO signaling pathway, AminoacyltRNA biosynthesis, and cGMPPKG signaling pathway were the major metabolism pathways disturbed in obese mice

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