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The effect of gamma-linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial

Activating GLP-1R inhibited TGF-1 + IL-1-induced fibroblast activation by disrupting the interaction between the NLRP3 inflammasome and PFKFB3-driven glycolysis and subsequently prevented lactate-mediated histone lactylation to reduce pro-fibrotic gene expression

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During the application of 100 nM exendin-4, integrated SNA increased and typically reached the peak at 34 min after start of the application, followed with the decrease (Fig