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The STEP trials for semaglutide and the SURMOUNT trials for tirzepatide both measured outcomes over 6872 weeks, and researchers have documented significant weight regain in patients who discontinue treatment prematurely

Their effects likely arise from a convergence of pathways: indirectly, through systemic improvements in glycemic control and metabolism, and directly, via the activation of intraocular GLP-1Rs on cells like retinal Mller and ganglion cells, which triggers local anti-inflammatory, anti-oxidant, and anti-apoptotic responses

Review the MOTS-c side effects guide and consult a qualified healthcare provider before starting

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So, you got to make sure your vitamin D levels are good