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The Bcl-2 family, in contrast, includes Bcl-2, which can protect cells from various apoptotic triggers, and Bax, an apoptosis agonist that acts through heterodimerisation with Bcl-2 [43]

Although peroxisomes are richly equipped with catalase (and peroxiredoxins such as Prx5) to shape the lifetime of H 2 O 2 , this oxidant can traverse peroxiporins to the cytosol, enabling peroxisome-to-cytosol redox signalling and metabolic coordination with mitochondria (e.g., matching fatty-acid flux with mitochondrial respiration) (Lismont et al

Many studies did not report critical aspects such as blinding, randomization, and power analysis

Human research remains limited and continues to evolve alongside mechanistic studies

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