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Optimal results require combining the peptides cellular effects with appropriate nutrition providing caloric deficit, regular cardiovascular exercise to oxidize mobilized fatty acids, and resistance training to preserve muscle mass during fat loss

Early animal studies showed promising results, with obese mice losing significant body fat without changes in food intake or lean muscle mass

Pharmacological treatments are reserved for specific circumstances and limited to licensed medications with demonstrated efficacy and safety profiles, such as orlistat or semaglutide (NICE TA875)