Combining them does not necessarily increase the risk of side effects, but it may make it harder to determine which product is causing a specific symptom if one arises
In clinical trials, treatment with tirzepatide produced superior weight loss and glycemic control compared to GLP-1RAs 3,17 , suggesting that agonism at both the GIPR and GLP-1R is beneficial in humans with type 2 diabetes
PMID: 16 LiuYGuW
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The pathological association between nutrition and OA Obesity and OA: intertwined pathways of inflammation, mechanics, and diet Obesity is a critical risk factor for OA, driven by a synergy of mechanical overload and adipose tissue-mediated systemic inflammation
