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In contrast to the GSSCys assay, the k cat app / K m app values highly depended on the substrate concentration and differed from the 1/ values by up to one order of magnitude

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The main targets in these models are thyroid follicular cells, immune cells (particularly T lymphocytes), and the autoantibodies that bind to thyroid antigens

With this rapid influx of information, however, comes a tidal wave of questions and, frankly, a lot of confusion