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The last 5 years have seen the emergence of efficacious peptide-based therapies for obesity treatment that target glucagon-like peptide-1 receptor (GLP-1R), either selectively or via co-activation with related receptors, such as the glucose-dependent insulinotropic polypeptide and/or glucagon receptors 1

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The methyltransferase DOT1L controls activation and lineage integrity in CD4 + T cells during infection and inflammation

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Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

This approach inevitably excludes some less-studied conditions, particularly those with very small patient populations or those that have only recently been the focus of pharmaceutical interest, but it nonetheless captures the lions share of DHT investment and innovation in the rare disease space