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GPX4 and glutaminase inhibitors can inhibit pyrimidine synthesis and increase ROS levels in VHL-deficient renal carcinoma cells, and the PARP inhibitor olaparib and glutaminase inhibitors can synergistically inhibit the growth of these cells in vivo and in vitro

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doi: 10.1111/cen.13474

Nutrients 15 (18), 3866

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Lower-cost versions can drive volume growth in high-need markets, but faster-than-expected price erosion across multiple countries could reduce the categorys overall revenue potential and raise the bar for next-generation obesity drugs to justify premium pricing