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Structural improvements including firmness, fine line reduction, and collagen density changes become visible between weeks 6 and 12, as the first full collagen remodeling cycle completes

To evaluate the healing efficacy, a comprehensive experiment was conducted on diabetic wounds treated with various agents, including: i) PBS as negative control (NC group), ii) ROS-responsive hydrogel matrix (G group), iii) monomer copper peptides M-CuP solution (M-CuP group), iv) dimeric copper peptides D-CuP solution (D-CuP group), v) ROS-responsive hydrogel with monomer copper peptides M-CuP (G/M-CuP group), and vi) ROS-responsive hydrogel with dimeric copper peptides (G/D-CuP group)

Zuo P, Ogita K, Suzuki T, Han D, Yoneda Y

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Results clearly present the chemical potentiation of LASSS on physiological functions of HGF, as revealed by enhanced receptor-binding affinity and nitration-dysfunction resistance through interaction/reaction with LASSS under physiological conditions

Sternberg, C