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Angiotensin III (Arg-Val-Tyr-Ile-His-Pro-Phe) binds at the AT 1 but primarily at the AT 2 receptor subtype and modulates cell proliferation, cell differentiation, and apoptosis

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Accordingly, in some embodiments, cyclodextrins are included to increase the solubility of the therapeutic agents, or auris-acceptable otic agents, within the formulations or compositions described herein