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These may include: Fluid retention and edema (swelling in the hands and feet) Joint pain and muscle aches Carpal tunnel syndrome Increased insulin resistance and associated diabetes risk with prolonged use Gynecomastia (enlarged breast tissue in men) Potential suppression of natural pituitary function These effects are more likely to occur because synthetic HGH provides constant, unregulated hormone levels rather than the natural pulsatile (rhythmic) secretion pattern the body is designed to produce

[50] However, it is important to note that fenfluramine, rimonabant and lorcaserin used very different molecular mechanisms (acting mainly on serotonin 2c receptors [51] in the hypothalamus [52] or CB1 receptors [53] ) from GLP1R, GIPR or GR agonists and likewise do not imply anything on the possible dangers of GLP1R, GIPR or GR agonists

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