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Genes involved in antioxidant defense and the ubiquitin proteasome system were also upregulated

The TRANSCEND-T2D-1 trial (NCT06354660) demonstrated HbA1c reductions of 1.7-2.0% and 36.6 lbs mean weight loss in type 2 diabetes participants over 40 weeks

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Furthermore, dihydroethidine (DHE) staining showed that the proportion of DHE-positive cells after OGD treatment was higher than that in the control group, suggesting that the level of reactive oxygen species (ROS) was increased (Figure 3G)