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Indications of Tirzepatide: Tirzepatide is approved for two primary indications: (1) Type 2 diabetes: Marketed as Mounjaro, clinical trials (SURPASS series) showed HbA1c reductions up to 2.4%, with some patients achieving normoglycemia

Epidemiological studies have also demonstrated that the use of metformin in individuals with type 2 diabetes is associated with a lower risk of PD [26]

Given that early differentiation proceeds from naive CD4 T cells 58 , we set the IL7R low naive CD4 T subset as the starting cluster

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