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The present review ultimately weighs early concerns against increasingly consistent evidence that GLP-1 RA use does not raise overall cancer risk, clarifies that breast cancer risk appears neutral, and further highlights key mechanisms, such as the reduction of hyperinsulinemia and immune-microenvironment modulation, through which these drugs may improve rather than exacerbate malignancy outcomes

Given these serious iatrogenic consequences, hPSC transplantation currently remains viable only for the treatment of critical, life-threatening conditions where the potential benefits outweigh these substantial risks

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