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The most common adverse effects from the SURMOUNT trials include: Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-25% of participants Constipation: 13-17% of participants Vomiting: 8-12% of participants Decreased appetite: 10-15% of participants Most of these effects are mild to moderate and occur primarily during dose escalation periods

With all that considered, we think its to Pendulums credit that it has responded to nearly every complaint with an apology, an explanation of circumstances, or an offer for further support

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The STEP 1 extension study showed approximately two-thirds of weight was regained within one year of stopping semaglutide