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ROS act as secondary messengers to activate inflammasomes such as NLRP3, promoting the release of IL-1 and IL-18, and fostering the senescence-associated secretory phenotype (SASP)

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Additionally, Soucy et al

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WD increased inflammation in a sex- and region-specific manner, and GE2 reduced inflammation in the hippocampus in SD-fed rats, as well as in the amygdala of males regardless of diet Brain aging is associated with increased inflammation, however diets, such as the WD, may further affect inflammation