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Using doses below the therapeutic threshold may provide insufficient metabolic benefit, essentially exposing patients to medication risks without meaningful clinical gain

Amelioration of muscle wasting by glucagon-like peptide-1 receptor agonist in muscle atrophy

Zinman B, Inzucchi SE, Lachin JM, Wanner C, Ferrari R, Fitchett D, Bluhmki E, Hantel S, Kempthorne-Rawson J, Newman J, Johansen OE, Woerle HJ, Broedl UC

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However, a study by Nauck et al

Obesity-related healthcare spending averages $1,861 per person per year above healthy-weight peers, in 2019 dollars, according to the CDC