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Since many antibodies against different dengue serotypes are cross-reactive but non-neutralizing, secondary infections with heterologous strains can result in increased viral replication and more severe disease, leading to major safety risks as reported in a recent dengue vaccine trial 13,14
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This increasing pro-inflammatory mediator expression is associated with the phosphorylation of MAPKs within 1530 min after LPS stimulation (4648)
h 2 o h 2 o2 Glutathione Peroxidase GSSG GSh Glutathione reductase Glutathione S-transferase nADPh nADP+ GSh Conjugate Glutathione S-transferases (GST) are an important group of enzymes that catalyze the nucleophilic addition of GSH to electrophiles
Notice how quickly the evidence strength column drops once you leave each drugs own trials
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