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The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

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This phase is about building tolerance, not maximizing results

Retatrutide is still an experimental drug in clinical trials

It's an investigational drug currently in Phase 3 clinical trials

Another potential pathway that enhances FXR activity involves the release of the growth factor fibroblast growth factor (FGF) 19 from the intestine upon bile acid binding to FXR, 66 which has shown beneficial effects on MASH in animal models, although results are conflicting