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However, oral semaglutide contains an absorption enhancer that may enter breast milk with unknown effects, so only injectable formulations are considered appropriate during breastfeeding

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Accessed October 3, 2024

however, some discontinuations were actually due to "perceived excessive weight loss," highlighting the potency of the drug

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329,330 In degenerative joint diseases like OA, the metabolic balance of chondrocytes is disrupted, leading to the overproduction of degrading enzymes and inflammatory mediators, including iNOS, MMP-13, and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), which participate in cartilage degradation and inflammatory processes