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Discovered in 2015 by researcher Changhan David Lee and colleagues at the University of Southern California, MOTS-c sits at the intersection of some of the most active areas in longevity science: mitochondrial biology, insulin sensitivity, skeletal muscle metabolism, and the molecular response to exercise

The mechanism that lowers postprandial glucose also means the stomach retains contents longer, which is relevant to anyone with pre-existing gastroparesis or significant GI motility disorders, and is a theoretical consideration around procedures requiring an empty stomach