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5 CRS and biomarkers 5.1 Existing biomarkers in CRS The initial definition of CRS was that it is the outcome of interactions between the renal and other circulatory compartments that increased circulating volume, exacerbated symptoms, and disease progression of patients with HF (Rangaswami et al., 2019)

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(2) Combination therapy approaches: some drugs currently used for inflammation-related diseases may have limited efficacy and narrow treatment window, such as NAC, and studies have indicated the stronger therapeutic effect of co-treatment of SA and NAC than monotherapy with NAC, which provided a novel insight into the clinical treatment strategies