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Furthermore, while semaglutide is generally considered safe for individuals with mild to moderate kidney impairment, there remains a lack of robust long-term data on its safety in advanced CKD[47,76,77]

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Int J Mol Sci 24(6):5079 Frat U, Kaya S, im A, Bykbayram H, Gkalp O, Dal MS, Tamer MN (2012) Increased caspase-3 immunoreactivity of erythrocytes in STZ diabetic rats

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Concomitant use with non-potassium sparing diuretics may increase risk