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doi: 10.1007/S00253-023-12656-4

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SMR insights into the causal relationship between GLP-1RA and DR In the SMR analysis between blood GLP-1R target gene expression and DR risk, we visualised the SNP distribution and P -value relationship between the eQTL dataset and the GWAS dataset for DR, where the labelled dots are the instrumental variable top-SNPs (usually those with the smallest P -value in the exposure dataset), and the red line represents P = 0.025, above which indicates significant statistical significance, while the opposite does not suggest a significant cause-and-effect relation between exposure and outcome (Fig

Peak weight loss per the STEP trial trajectory occurs at approximately 6068 weeks of continuous use at maintenance dose