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Compounded semaglutide Nausea Constipation Fatigue Variable response depending on formulation Some users report stronger or milder effects based on how its made or delivered Ozempic Nausea Diarrhea Bloating or gas Usually predictable due to standardized formulation Vomiting Many people sharing their semaglutide before and after stories say that how well they tolerated side effects like nausea or fatigue depended on whether they used Ozempic or a compounded version

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Therefore, the Food and Drug Administration (FDA) released a guidance requiring all new drugs for glycemic control in T2DM patients to demonstrate cardiovascular safety, a policy that was continued and further emphasized in the 2020 FDA Guidance for Diabetes Drug Development [7, 8]