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Active pancreatitis

MTHFR variants like C677T can raise homocysteine and increase demand on the folate and B12 methylation pathway, but they do not by themselves cause deficiency

The cumulative antioxidant activity could be very high with the reactivation of the carboxylic groups (e.g., glutathione or enzymes)

Consult with your healthcare provider to determine if MIC+B12 is right for you

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Seiwerth and colleagues (Inflammopharmacology, 1999) documented effects on angiogenic growth factor pathway signalling, and subsequent work has expanded characterisation to include VEGF receptor 2 upregulation, endothelial cell migration in capillary-formation assays, and improved healing in ischemia-reperfusion preparations