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Acknowledgements We thank FigDraw (www.figdraw.com) for creating the model images and granting us copyright ownership

Propensity scores for each outcome were calculated based on the probability of initiating treatment with GLP-1RA taking into account the same covariates, to generate patient-specific stabilised weights

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Benefits: Maintains testicular size and function Preserves fertility during TRT Increases testosterone (when used alone) Prevents testicular atrophy Dosing: 250-500 IU subcutaneous, 2-3x weekly alongside TRT Higher doses (500-1000 IU 3x weekly) for fertility maintenance Best for: Men on TRT who want to maintain fertility and testicular function

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Experiments were repeated three times independently, three mice per condition each time