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2013 Jan 11;288(2):837-47

B12 is safe on its own, but a few conditions call for extra care, which is why a provider reviews your history before treatment: Leber's hereditary optic neuropathy, a rare inherited eye condition, where certain forms of B12 may be a concern for the optic nerve

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Reduce the risk of cognitive decline and Alzheimers disease (11) Treat pernicious anemia, a condition that can cause nerve damage and increases your risk of stomach cancer (12)

[1] [3] Rapid or excessive infusions can disturb electrolytes or cause fluid overload, though this is rare with proper dosing and monitoring