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MAPK pathways regulate cardiomyocyte proliferation, stress responses, and inflammatory gene expression, while the PI3K/Akt pathway contributes to endothelial nitric oxide production, cell survival, and the inhibition of apoptosis [17,18]

The relevance of rodent thyroid findings to human physiology remains debated

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The lower affinity could be partially explained by a reduction in the absolute negative charges of the Ent1/2 and Ent5.1 CBMs (from 4 to 1)

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