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the rate in the placebo-treated group was 3.2 episodes per 100 patient years of exposure

Perrone, G

Classical macrophages (M1) are responsible for triggering the inflammatory response via the secretion of pro-inflammatory cytokines and reactive oxygen species (ROS)

With the coenzyme as hydrogen donor, GSSG can be reduced to GSH under the catalysis of GSR, causing an increase in GSH concentrations and a decrease in NADPH concentrations

Recent meta-analyses highlight significant heterogeneity in study designs, dosing protocols, and outcome measures, making it difficult to draw definitive conclusions about EGCGs therapeutic efficacy

Because of its anti-inflammatory and antioxidant effects, it can potentially reduce local oxidative stress in the ovary and endometrium and improve both oocyte quality and endometrial milieu when paired with conventional ovulation induction or IVF protocols