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The risk of gastric ulcers and gastrointestinal bleeding is a well-established concern with NSAIDs, particularly with prolonged use, higher doses, or in patients over 65 years of age

This supports a treat-to-target paradigm in obesity, aiming for substantial and sustained weight loss beyond the older 510% goals. 17 Waist circumference matters: pooled data show each 5 cm reduction is associated with 7% lower mortality in men, 9% in women

It is advisable to discuss this with their healthcare provider, who may recommend alternative methods during the first few weeks of treatment or after any dosage changes

B., Kolenc, D., Aralica, G., Misic, M.,

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