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The gut microbiota plays an important role in the function of the immune system and metabolic activity (148150)

what are their toxicities, adverse effects or even their drug interactions

It has been studied extensively in colitis models, where it reduces intestinal inflammation through the same NF-kB suppression mechanism that benefits skin inflammation

165 Interestingly, the 5 promoter region of the human CD38 gene contains binding sites for several cytokines, such as TNF, NF-IL6, IL13, and IL4

Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Struijker Boudier HA, Zanchetti A