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Crucially, glucagon receptor activation increases energy expenditure and promotes preferential utilization of fat stores, creating a metabolic environment optimized for fat oxidation rather than muscle catabolism

NICE Technology Appraisal (TA875) recommends semaglutide (Wegovy) only for adults with at least one weight-related comorbidity and a BMI 35 kg/m (or 32.5 kg/m for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean backgrounds)

Here is what that means in practical terms

Look how good

GLP-1 suprime efectivamente el glucagn, retrasa el vaciamiento gstrico y reduce el apetito, mientras que GIP tiene efectos menos consistentes sobre estos procesos y acta ms sobre el metabolismo de lpidos

However, medical professionals generally recommend baseline metabolic panels, thyroid function tests, and kidney function assessments before starting GLP-1 therapy