Bioresour Technol 131:2832
Mutant lines were developed in Georg Janders lab that lack enzymes involved in nicotine biosynthesis (the reductase A622 and Putrescine methyltransferase PMT), with the A622-deficient line (a622) showing lower nicotine levels and a cold-sensitive, dwarf phenotype leading to the hypothesis that nicotine may be related to plant growth, and therefore, that a nicotine-producing rootstock may rescue the dwarf phenotype
The various names can be confusing, but they all refer to the injection of a gel-like substance, often derived from rooster combs, into the knee joint
doi: 10.1093/brain/awx113 137 KrasemannSMadoreCCialicRBaufeldCCalcagnoNEl FatimyRet al
Use with caution in patients with kidney disorders where high-dose Vitamin C is not advisable
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