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Beta-3 adrenergic receptors are particularly concentrated in adipose tissue, especially visceral (intra-abdominal) and brown adipose tissue

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[15] that included patients with intracranial hypertension and a self-reported sulfa allergy found that 37% of patients on acetazolamide and/or furosemide had no cross-reactivity, 56% had predictable adverse reactions specific for the medication, and 7% of the cases had urticaria

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