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Figure 1 2 MASLDs pathophysiology and current treatment MASLD is characterized by an abnormal accumulation of lipids in hepatocytes, commonly occurring in the context of obesity, insulin resistance, and T2DM-key features of metabolic syndrome that substantially affect patient quality of life and long-term prognosis (1)

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doi: 10.3390/MICROORGANISMS10122507 104

Moreover, this epigenetic regulation supports cardiomyocyte growth and proliferation while simultaneously suppressing pro-fibrotic signaling pathways, including TGF-, thereby facilitating the development of a physiological hypertrophic phenotype (197)