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Microarray and RNA-sequencing studies have mapped its regulatory effect across approximately 4,000 human genes, including upregulation of VEGF, BDNF, and BMP-2 growth factors central to vascular, neural, and bone remodeling respectively

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The evidence supports a limited association, not broad screening based on B12 alone

In the Euro Disc study, CLCs were obtained from 112 human patients with IVD herniation who underwent discectomy, subsequently culture-expanded and after 12 weeks percutaneously re-injected into the IVD [23]

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