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Detox Symptoms Frequent enema use may cause the following adverse effects [70+]: Cramping, stomach pain, bloating, and diarrhea Bowel stretching leading to constipation Nausea and vomiting Headaches, dizziness, and fatigue Bowel injuries and irritation Kidney, heart, and liver failure Infections from improperly sterilized kits While proponents often claim some of them (particularly nausea, headache, dizziness, and fatigue) are detox symptoms, these side effects are most likely caused by bowel stretching and electrolyte imbalances