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In the most recent American Association of Clinical Endocrinology clinical practice guidelines for the diagnosis and management of NAFLD it was recommended to administer pioglitazone (PIO) or glucagon-like peptide 1 receptor (GLP-1R) agonists with proven benefit for patients with T2D and biopsy-proven NASH, while these medications should be considered when there is high probability of having NASH (based on higher plasma aminotransferase levels and non-invasive tests) [40]