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Pharmacokinetic studies in rodents have focused on either free SFN or its metabolite SFN-glutathione

This phenomenon, known as metabolic endotoxemia, has been linked to: Chronic inflammation Insulin resistance Obesity Metabolic syndrome In animal studies, even modest increases in circulating endotoxins have been shown to trigger inflammatory responses that interfere with metabolic regulation

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doi: 10.1124/dmd.31.6.705

This was illustrated in the therapy of the bleeding disorders (Stupnisek et al., 2012