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Semaglutide and other GLP-1 agonists actually improve glucose metabolism but work through appetite suppression rather than direct fat cell targeting

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NNMT inhibition via 5-Amino-1MQ was associated with higher NAD+ levels, thereby influencing sirtuin activation and mitochondrial function

The peptides specific targeting of NNMT-expressing adipocytes allows for a localized metabolic shift without widespread systemic overstimulation, presenting a unique model for selective fat mass modulation studies