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This phase 3 multicenter study, which is coordinated by Cleveland Clinics C5Research academic research organization, is enrolling 15,000 adults with overweight or obesity (BMI 27) who do not have diabetes but do have either established CVD or multiple CVD risk factors

Winning will require both safety and efficacy The next wave of competition will not be driven by efficacy alone

Across major GLP-1/GIP clinical trials: Lean mass accounts for about 2540% of total weight lost meaning roughly 6075% is fat loss

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One small human study in people with type 2 diabetes found that 1,500 mg of curcumin daily reduced weight and blood sugar modestly

Hair loss, for example, is common in any individual who loses a substantial amount of weight