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Clinical endpoints included the Ocular Surface Disease Index (OSDI), FACES scale, tear film break-up time (TFBUT), Schirmer test, and NEI fluorescein staining

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Studies show oxidative degradation and peptide aggregation increase beyond this window, reducing bioavailability by 1020% or more depending on storage conditions

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Peptides versus other regenerative modalities Platelet-rich plasma (PRP) injections represent the primary clinical alternative for regenerative support