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Their FAO suppression leads to reduced fatty acid breakdown and lipid accumulation, forming lipid-laden macrophages. These macrophages have severely impaired phagocytic function and cannot effectively clear apoptotic cells, foreign bodies, and cigarette smoke particles, further exacerbating the stability of the inflammatory microenvironment

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Soto-Gutierrez, A., Gough, A., Vernetti, L

Most patients notice reduced hunger within 37 days of a 5-unit dose, but measurable weight loss (13 pounds) typically appears within 24 weeks